NPR's Up First newsletter reports that Nvidia's board announced CEO Jensen Huang is stepping down over reported extramarital affairs — including with a client U.S. intelligence officials concluded was recruited by China's top spy agency — with CFO Colette Kress named interim CEO and the share price falling sharply, and that Sen. Chris Van Hollen says he will challenge Chuck Schumer for Senate majority leader. It also covers Steve Witkoff and Jared Kushner's Ukraine peace talks, the American Cancer Society's first recommendation of routine prostate screenings, and Life Kit's Thanksgiving hosting advice.